Older adults who maintain exceptionally fast walking speeds into their eighties tend to experience less cognitive decline and have a lower risk of developing cognitive impairment. New research published in the journal Neurology indicates that these individuals, dubbed “super movers,” do not necessarily have less Alzheimer’s-related brain pathology but instead possess structural advantages in the brain that might help them cope with aging. These findings provide evidence that superior physical mobility in late life acts as a strong marker of brain resilience.
Walking speed is a well-established marker of overall health in older age. As people age, their gait naturally slows down. A small subset of the population maintains walking speeds well above average into their eighties and nineties. Scientists call these older adults “super movers.”
Previous research indicates that super movers tend to have fewer chronic health conditions, healthier lifestyles, and a younger biological age than their peers. Because physical health is closely tied to brain health, scientists wanted to see if this exceptional physical mobility translates to better mental function.
“Most research focuses on why people walk slower as they age,” said Joe Verghese, a professor and chair of neurology at Stony Brook University. “We wanted to understand the opposite: why some adults over 80 maintain exceptional mobility and whether that reflects healthier brain aging.”
The rationale for the study was to explore whether super movers have a lower risk of developing cognitive impairments or dementia. The authors also wanted to examine whether these individuals have healthier brain structures or less buildup of the physical markers associated with Alzheimer’s disease. To answer these questions, the researchers combined data from three distinct, large-scale health databases.
First, the authors analyzed data from an international network of health and retirement studies. This sample included 3,989 adults aged 80 and older from the United States, England, Europe, China, and Mexico. None of these individuals had Alzheimer’s disease or dementia at the beginning of the study.
The researchers defined super movers as those whose walking speeds were at least 1.5 standard deviations above the average for their specific age and sex. A standard deviation is a statistical measure that shows how much variation exists from the average. This means these super movers were in roughly the top seven percent of walkers for their demographic.
The researchers then tracked the participants for an average of 3.4 to 5.4 years. They monitored the subjects to see who developed cognitive impairment. The findings suggest that super movers have a notably lower risk of experiencing cognitive decline.
Super movers had a 51 percent lower relative risk of developing new cognitive impairment compared to regular movers. Out of the 3,715 participants analyzed for this specific risk, the overall incidence of cognitive impairment was much lower for those with exceptional walking speed. “The effect size was large,” Verghese said. “Super movers had about a 50% lower risk of developing cognitive impairment than their peers.”
This reduced risk was consistent even after adjusting for basic demographic factors like age and sex. The researchers also accounted for the participants’ baseline cognitive performance before the follow-up period. The data provides evidence that super mobility in late life acts as a robust indicator of future cognitive health.
Next, the researchers looked at data from the LonGenity study, which tracks the health of older adults of Ashkenazi Jewish descent. This portion included 197 adults aged 80 and older who underwent annual cognitive tests for an average of 4.4 years. The cognitive tests measured functions like memory recall, mental processing speed, and visual-spatial skills.
A smaller subset of 64 participants also received magnetic resonance imaging, or MRI, to measure brain structure. An MRI is a medical imaging technique that uses magnetic fields to create detailed pictures of the organs and tissues within the body. In this sample, super movers showed a slower rate of decline in both memory and non-memory tasks.
They specifically maintained better processing speed and visual-spatial skills over time. The brain imaging data indicated that super movers had larger volumes in the hippocampus. The hippocampus is a brain region deeply involved in memory formation and spatial navigation.
Specifically, super movers had more volume in the right hippocampus and in localized sub-regions associated with memory and movement. However, the differences in overall cortical thickness were not statistically significant between the two groups. Cortical thickness refers to the width of the outer layer of the brain, which typically thins as people age.
Finally, the authors analyzed autopsy data from a memory and aging project based at RUSH University. This included 692 participants aged 80 and older who had their walking speed measured during life and consented to brain autopsies after death. The researchers examined the brains for physical signs of dementia.
These signs include amyloid plaques and tau tangles. Plaques and tangles are abnormal protein clusters that build up in the brains of people with Alzheimer’s disease. The authors compared the post-mortem brain tissue of super movers to that of regular movers.
Before death, the super movers in this group demonstrated better overall cognitive performance and lower rates of diagnosed Alzheimer’s disease. When examining the brains post-mortem, the authors found no differences in the amount of Alzheimer’s-related plaques and tangles between super movers and regular movers. “Super movers had better cognitive outcomes despite having similar Alzheimer’s pathology at autopsy,” Verghese said.
“That points toward resilience rather than simply having less disease,” Verghese continued. This suggests that super movers do not necessarily avoid the physical brain pathology of aging. Instead, their brains might possess a form of resilience that allows them to maintain sharp mental function. They seem able to cope with the presence of these disease markers better than people with slower walking speeds.
The observational nature of this research leaves open the question of direct cause and effect. The strong relationship between walking speed and brain health does not mean that walking fast directly prevents cognitive decline. A person cannot simply force themselves to walk faster to stave off dementia.
“This is an observational study,” Verghese noted. “We cannot conclude that walking faster prevents dementia, only that exceptional mobility is associated with healthier cognitive aging.” Exceptional walking speed and sharp cognition are likely both outward signs of an underlying resilience in the brain and body.
The threshold used to define super movers is based on statistical averages rather than a strict biological cutoff. This means the specific walking speed required to be a super mover can vary depending on a population’s overall health and average physical fitness. Using relative statistical cutoffs makes it hard to create a universal clinical standard for what constitutes a super mover.
The autopsy sample also consisted mostly of highly educated, health-conscious volunteers. This demographic skew limits how well these specific autopsy findings apply to the general public. Future research will need to examine physical brain pathology in more diverse, globally representative populations.
Scientists hope to identify specific lifestyle factors, such as dietary habits and sleep quality, that support brain resilience. Understanding how environmental conditions and community infrastructure support exceptional aging could inform public health strategies. “We want to identify the biological, lifestyle, and environmental factors that make someone a super mover, with the goal of developing strategies to promote healthy brain aging for everyone,” Verghese said.
Identifying the behavioral and biological traits of super movers might eventually help health professionals preserve cognitive function in all older adults. “Faster walking in later life is a marker of healthy brain aging,” Verghese explained. “Staying active throughout life is one of the best things we know to support both physical and cognitive health.”
Looking forward, the researchers emphasize the importance of positive aging models. “Studying people who age exceptionally well can be just as informative as studying disease,” Verghese said. “They may reveal new pathways to maintaining cognitive health into very old age.”
The study, “Cognitive Aging and Brain Health: A Comparison of Super Movers vs Nonsuper Movers,” was authored by Oshadi Jayakody, Sofiya Milman, Nir Barzilai, Erica F. Weiss, Cuiling Wang, Ying Jin, Helena Blumen, and Joe Verghese.
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